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It is bordered to the south with the Selous Game Reserve and the two areas forming a unique ecosystem. Two other natural areas bordering the national park are the Udzungwa Mountains and Uluguru Mountains. The landscape of Mikumi is often compared to that of the Serengeti. The road that crosses the park divides it into two areas with partially distinct environments. The area north-west is characterized by the alluvial plain of the river basin Mkata. The vegetation of this area consists of savannah dotted with acacia, baobab, tamarinds, and some rare palm.